Fraser A G, Sawyerr A M, Hudson M, Smith M, Pounder R E
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Dig Dis Sci. 1994 Jan;39(1):91-6. doi: 10.1007/BF02090066.
Twenty-four-hour integrated intragastric acidity and 24-hr integrated plasma gastrin concentration was measured twice in 23 healthy male volunteers on the seventh day of oral dosing with placebo or ranitidine 150 mg four times a day. The study was a randomized, double-blind, placebo-controlled, two-way crossover investigation. The mean integrated 24-hr intragastric acidity during dosing with ranitidine 150 mg four times a day decreased to 32% of the placebo value (placebo 825 mmol/hr/liter; ranitidine 265 mmol/hr/liter). The mean integrated 24-hr plasma gastrin concentration during dosing with ranitidine 150 mg four times a day was 904 pmol/hr/liter compared with placebo (410 pmol/hr/liter)--an increase of 122%. The median number of hours of pH > 3 during dosing with placebo and with ranitidine 150 mg four times a day were 5 and 11 hr, respectively. Ranitidine 150 mg four times a day caused a significant decrease of mean integrated intragastric acidity for each meal-related interval and also during the night.
在23名健康男性志愿者口服安慰剂或每天4次服用150毫克雷尼替丁的第7天，测量了24小时综合胃内酸度和24小时综合血浆胃泌素浓度，测量进行了两次。该研究是一项随机、双盲、安慰剂对照的双向交叉调查。每天4次服用150毫克雷尼替丁期间，24小时综合胃内酸度均值降至安慰剂值的32%（安慰剂为825毫摩尔/小时/升；雷尼替丁为265毫摩尔/小时/升）。每天4次服用150毫克雷尼替丁期间，24小时综合血浆胃泌素浓度均值为904皮摩尔/小时/升，而安慰剂为410皮摩尔/小时/升，增加了122%。服用安慰剂和每天4次服用150毫克雷尼替丁期间，pH>3的中位数小时数分别为5小时和11小时。每天4次服用150毫克雷尼替丁会导致每餐相关时间段以及夜间的平均综合胃内酸度显著降低。
