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A new application for liposomes in cancer therapy. Immunoliposomes bearing enzymes (immuno-enzymosomes) for site-specific activation of prodrugs.

作者信息

Vingerhoeds M H, Haisma H J, van Muijen M, van de Rijt R B, Crommelin D J, Storm G

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, Utrecht University, The Netherlands.

出版信息

FEBS Lett. 1993 Dec 28;336(3):485-90. doi: 10.1016/0014-5793(93)80861-n.

DOI:10.1016/0014-5793(93)80861-n
PMID:8282116
Abstract

We have tested a new type of immunoliposomes which may effectively mediate the targeting of enzymes to be used for site-specific prodrug activation (immuno-enzymosomes). The enzyme beta-glucuronidase, capable of activating the prodrug epirubicin-glucuronide (epi-glu), was coupled to the external surface of immunoliposomes directed towards ovarian cancer cells. A significant increase in cytotoxicity of the prodrug epi-glu was shown when the in vitro cultured cancer cells were pretreated with these immuno-enzymosomes.

摘要

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