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新生儿中性粒细胞的吞噬作用及杀菌能力

[Phagocytosis and bactericidal capacity of polymorphonuclear neutrophils in neonates].

作者信息

Orzeszko-Spaczyńska A, Markwitz W, Wysocki H, Wierusz-Wysocka B, Szczepanik A, Słomko Z, Wykretowicz A

机构信息

Instytutu Pediatrii, Akademii Medycznej im. K. Marcinkowskiego, Poznaniu.

出版信息

Ginekol Pol. 1993 Apr;64(4):193-6.

PMID:8282242
Abstract

Phagocytosis and bactericidal capacity of polymorphonuclear neutrophils (PMN) obtained from umbilical venous blood was estimated in 30 neonates and their mothers by the use of fluorochrome microassay of Pantazis and Kniker. Phagocytosis of Staphylococcus was similar in both groups and controls, while intracellular bacteria killing was significantly impaired in PMN obtained from the neonates. These results may indicate that increased susceptibility to infection observed in neonates may be partly caused by PMN function impairment.

摘要

采用潘塔齐斯和尼克的荧光染料微量分析法,对30名新生儿及其母亲脐静脉血中的多形核中性粒细胞(PMN)的吞噬作用和杀菌能力进行了评估。两组及对照组中,葡萄球菌的吞噬作用相似,而从新生儿获取的PMN的细胞内细菌杀伤能力显著受损。这些结果可能表明,新生儿中观察到的感染易感性增加可能部分是由PMN功能受损引起的。

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