幽门螺杆菌感染是何时获得的？
When is Helicobacter pylori infection acquired?
作者信息
Cullen D J, Collins B J, Christiansen K J, Epis J, Warren J R, Surveyor I, Cullen K J
机构信息
Royal Perth Hospital, Australia.
出版信息
Gut. 1993 Dec;34(12):1681-2. doi: 10.1136/gut.34.12.1681.
Cross sectional surveys have shown an increasing prevalence of Helicobacter pylori (H pylori) infection with increasing age in Western populations. The aim of this study was to examine the pattern of acquisition of H pylori infection over a 21 year period in a group of 141 adults who had blood samples and serum stored in 1969, 1978, and 1990. A prevalence of H pylori antibody of 39% in 1969 serum samples, 40.9% in 1978, and 34.8% in 1990 was found when assessed by an enzyme linked immunosorbent assay (ELISA). Of the 86 subjects who were seronegative in 1969, only six (7%) were seropositive in 1990. These data suggest that a cohort effect may contribute to the pattern of increasing prevalence of H pylori infection seen with increasing age. Acquisition of infection in adults is rare. It is unlikely, therefore, that reinfection will occur after successful eradication.
横断面调查显示，在西方人群中，幽门螺杆菌（H pylori）感染率随年龄增长而上升。本研究的目的是在一组1969年、1978年和1990年采集了血样和血清的141名成年人中，研究21年间幽门螺杆菌感染的获得模式。通过酶联免疫吸附测定（ELISA）评估发现，1969年血清样本中幽门螺杆菌抗体阳性率为39%，1978年为40.9%，1990年为34.8%。在1969年血清学阴性的86名受试者中，到1990年只有6名（7%）血清学呈阳性。这些数据表明，队列效应可能导致了幽门螺杆菌感染率随年龄增长而上升的模式。成年人中感染的获得很少见。因此，成功根除后再次感染的可能性不大。
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