Battistel M, Plebani M, Di Mario F, Jocic M, Lippe I T, Holzer P
University of Graz, Department of Experimental and Clinical Pharmacology, Austria.
Gut. 1993 Dec;34(12):1688-92. doi: 10.1136/gut.34.12.1688.
Chronic cigarette smoking has adverse effects on peptic ulcer disease because the healing of ulcers is delayed and the incidence of relapses is enhanced. Short term intake of nicotine induces vascular damage in the rat gastric mucosa, but the pathophysiological mechanisms of nicotine's action in the stomach are largely unknown. In this study rats were treated with nicotine, added to their drinking water, for 50 days. They were then anaesthetised and their stomachs perfused with acidified acetylsalicylic acid (ASA). Chronic nicotine treatment failed to change the effects of acidified ASA to induce gastric mucosal acid back diffusion, haemorrhagic damage and bleeding. Basal blood flow in the gastric mucosa was also unchanged by chronic nicotine intake, whereas the mucosal hyperaemia evoked by ASA induced acid back diffusion was averted. The concentrations of sulfidoleukotrienes were significantly augmented in the gastric wall of nicotine treated rats. These data show that chronic nicotine intake causes dysregulation of the gastric microcirculation, an effect that is associated with biochemical changes in the stomach. This study thus substantiates the adverse effects of smoking on gastric mucosal pathophysiology. These data suggest that inappropriate regulation of gastric mucosal blood flow inhibits recovery from gastric mucosal injury in smokers.
长期吸烟对消化性溃疡病有不良影响，因为溃疡愈合延迟且复发率增加。短期摄入尼古丁会导致大鼠胃黏膜血管损伤，但尼古丁在胃中的作用的病理生理机制很大程度上尚不清楚。在本研究中，给大鼠饮用添加了尼古丁的水，持续50天。然后将它们麻醉，并用酸化的乙酰水杨酸（ASA）灌注其胃部。长期尼古丁治疗未能改变酸化ASA诱导胃黏膜酸反向弥散、出血性损伤和出血的作用。长期摄入尼古丁也未改变胃黏膜的基础血流量，而由ASA诱导的酸反向弥散引起的黏膜充血则得以避免。在尼古丁处理的大鼠胃壁中，硫代白三烯的浓度显著增加。这些数据表明，长期摄入尼古丁会导致胃微循环失调，这种效应与胃中的生化变化有关。因此，本研究证实了吸烟对胃黏膜病理生理学的不良影响。这些数据表明，胃黏膜血流调节不当会抑制吸烟者胃黏膜损伤的恢复。
