Ageel A M, Parmar N S, Tariq M
Life Sci. 1984 Feb 20;34(8):751-6. doi: 10.1016/0024-3205(84)90382-5.
The effect of nicotine pretreatment by feeding nicotine (5mcg/ml) in drinking water ad libitum for 10 days was studied on the aspirin and reserpine induced gastric mucosal damage in rats. The administration of nicotine resulted in the significant augmentation of aspirin (P less than 0.01) and reserpine (P less than 0.05) induced gastric ulcers. The mechanism(s) involving the sensitization of gastric mucosa towards the ulcerogenic effect of aspirin and reserpine may be responsible for the increased intensity of gastric ulcers in both the groups. The study indicates the possibility of a similar interaction in heavy smokers who ingest these drugs.
通过在大鼠饮用水中随意添加尼古丁（5微克/毫升）进行10天尼古丁预处理，研究其对阿司匹林和利血平诱导的大鼠胃黏膜损伤的影响。给予尼古丁导致阿司匹林（P<0.01）和利血平（P<0.05）诱导的胃溃疡显著加重。胃黏膜对阿司匹林和利血平致溃疡作用的致敏机制可能是两组胃溃疡强度增加的原因。该研究表明，在摄入这些药物的重度吸烟者中可能存在类似的相互作用。
