Chiesura P, Macaluso S
Lav Um. 1976 Jul;28(4):97-103.
Urinary lead excretion following EDTA administration was studied in 47 both normal and lead intoxicated subjects, mainly monitoring the rate of excretion through sequential urine samples. Urinary lead excretion patterns proved to be quite different in the examined subjects: in particular, great differences were noted in the onset of lead excretion increase. The six-hr lead excretion resulted to be 60,7% of the total 24-hr excretion, with, however, a very wide range (42% to 83%). Urine flow didn't appear to influence the rhythm of urinary lead excretion. There is sufficient evidence to justify the conclusion that evaluation of EDTA-induced urinary lead excretion on the basis of the first-six-hr results cannot be assumed as a reliable procedure, unless it is used for rough diagnostic screening purposes.
对47名正常和铅中毒受试者进行了研究，观察静脉注射依地酸二钠钙（EDTA）后尿铅的排泄情况，主要通过连续采集尿样来监测排泄速率。结果表明，受检者的尿铅排泄模式有很大差异：尤其是在尿铅排泄增加的起始时间上有显著不同。6小时尿铅排泄量占24小时总排泄量的60.7%，但范围很宽（42%至83%）。尿流似乎不影响尿铅排泄的节律。有充分证据支持以下结论：除非用于粗略的诊断筛查，否则基于前6小时结果评估依地酸二钠钙诱导的尿铅排泄不能被视为可靠的方法。
