Dutz W, Post C, Jennings-Khodadad E, Fakouhi T, Kohout E, Bandarizadeh B
Natl Cancer Inst Monogr. 1976 Oct;43:179-85.
Pentamidine isethionate and sulfadoxine plus pyrimethamine are excellent therapeutic agents in experimental and hypoergic, hypoimmune pneumocystosis as well as in focal interstitial plasma cell pneumonia (IPCP) in infants. Their effectiveness is seriously limited in cases in which either a diffuse massive plasma cell exudate has been established or in adults in whom the phagocytic and resorptive facility is depressed. Infantile pneumocystosis leading to IPCP can be completely prevented by proper feeding and care of the patient or prophylactic drug therapy with sulfadoxine-pyrimethamine. Similar measures should be taken for adult patients at risk in hospitals where pneumocystosis is frequent or when pneumocystosis has been recently diagnosed.
乙磺半胱氨酸戊烷脒以及周效磺胺加乙胺嘧啶，在实验性、低反应性、低免疫性肺孢子虫病以及婴儿局灶性间质性浆细胞肺炎（IPCP）中是极佳的治疗药物。在已形成弥漫性大量浆细胞渗出的病例中，或者在吞噬和吸收功能低下的成年人中，它们的有效性受到严重限制。通过对患者进行适当的喂养和护理，或使用周效磺胺 - 乙胺嘧啶进行预防性药物治疗，可以完全预防导致IPCP的婴儿肺孢子虫病。对于医院中易患肺孢子虫病风险的成年患者，或者最近被诊断出患有肺孢子虫病的患者，应采取类似措施。
