Sakakibara R, Hattori T, Tojo M, Yamanishi T, Yasuda K, Hirayama K
Department of Neurology, Chiba University School of Medicine, Japan.
J Auton Nerv Syst. 1993 Nov;45(2):101-6. doi: 10.1016/0165-1838(93)90122-b.
Detailed micturitional histories were taken from nine patients with progressive supranuclear palsy (PSP), and eight of them (89%) had micturitional symptoms including urinary incontinence in seven. Urodynamic studies were performed in six patients and the results were as follows. Three had residual urine of 100 ml on average. Four had detrusor hyperreflexia and one had a low compliance cystometrogram. One had detrusor-sphincter dyssynergia. Motor unit analysis of external sphincter was performed in four patients and two had neurogenic changes. The results were compared with our previous findings in Parkinson's disease and in striato-nigral degeneration (SND), and we found that a severe degree of micturitional disturbance in PSP seems to be as common as in SND, especially in the urinary storage phase, and more frequent than in Parkinson's disease. Supranuclear types of pelvic and pudendal nerve dysfunctions seemed to be mainly responsible for micturitional disturbance in PSP.
我们收集了9例进行性核上性麻痹（PSP）患者详细的排尿病史，其中8例（89%）有排尿症状，包括7例尿失禁。对6例患者进行了尿动力学研究，结果如下。3例平均残余尿量为100 ml。4例逼尿肌反射亢进，1例膀胱顺应性降低。1例逼尿肌-括约肌协同失调。对4例患者进行了外括约肌运动单位分析，2例有神经源性改变。将这些结果与我们之前在帕金森病和纹状体黑质变性（SND）中的发现进行比较，我们发现PSP中严重程度的排尿障碍似乎与SND一样常见，尤其是在储尿期，且比帕金森病更频繁。核上型盆腔和阴部神经功能障碍似乎是PSP排尿障碍的主要原因。
