Radicati Fabiana Giada, Martinez Martin Pablo, Fossati Chiara, Chaudhuri Kallol Ray, Torti Margherita, Rodriguez Blazquez Carmen, Vacca Laura, Stocchi Fabrizio
Institute for Research and Medical Care IRCCS San Raffaele, Rome, Italy.
Carlos III Institute of Health and CIBERNED, Madrid, Spain.
NPJ Parkinsons Dis. 2017 Dec 8;3:35. doi: 10.1038/s41531-017-0037-x. eCollection 2017.
NMSs have been extensively studied in PD patients but not in other forms of parkinsonism such as Progressive Supranuclear Palsy (PSP). The primary objective of this study was to analyze the frequency, severity and the type of non-motor symptoms (NMS) in PSP patients using the non-motor symptoms scale (NMSS). The secondary objective was to differentiate NMS between PSP and Parkinson's disease (PD). We enrolled in this cross-sectional study 50 consecutive PSP and 100 matched Parkinson's disease (PD) patients, in the proportion PSP/PD = 1/2, matched in age, sex, and disease duration. Motor and Non Motor symptoms (different scales for each disease) were evaluated at baseline using PSP scale, SCOPA Motor, Montreal Cognitive Assessment (MOCA), HADS, Hamilton, and Non Motor Symptom scale (NMSS). Comparative analysis was done using chi-squared test, Mann-Whitney test and Fisher's exact test. Fifty PSP (56% female) and 100 PD (59% female) patients completed the study protocol and were included for statistical analysis. The NMSS total domains score in the PSP group was 77.58 ± 42.95 (range 14-163) with NMS burden grade: 4, very severe, and the in the PD group was 41.97 ± 35.45 (range: 0-215) with NMS burden grade: 3, severe. The comparative analysis showed that NMS total score ( < 0.0001), Sleep/Fatigue ( = 0.0007), Mood/Apathy ( = 0.0001), Gastrointestinal ( < 0.0001), and Urinary dysfunction ( = 0.0001) domains were significantly more severe in PSP patients than in PD. This observational study reports that NMSs are very frequent in PSP patients hence the higher burden of NMS in PSP specifically related to mood/apathy, attention/memory, gastrointestinal, urinary disturbances compared to PD.
人们已对帕金森病（PD）患者的非运动症状（NMS）进行了广泛研究，但尚未对进行性核上性麻痹（PSP）等其他形式的帕金森综合征患者进行研究。本研究的主要目的是使用非运动症状量表（NMSS）分析PSP患者非运动症状（NMS）的频率、严重程度和类型。次要目的是区分PSP和帕金森病（PD）患者的NMS。我们纳入了这项横断面研究，连续纳入50例PSP患者和100例匹配的帕金森病（PD）患者，PSP/PD比例为1/2，在年龄、性别和病程方面进行匹配。在基线时使用PSP量表、SCOPA运动量表、蒙特利尔认知评估（MOCA）、医院焦虑抑郁量表（HADS）、汉密尔顿量表和非运动症状量表（NMSS）对运动和非运动症状（每种疾病使用不同量表）进行评估。使用卡方检验、曼-惠特尼检验和费舍尔精确检验进行比较分析。50例PSP患者（56%为女性）和100例PD患者（59%为女性）完成了研究方案并纳入统计分析。PSP组的NMSS总分域得分为77.58±42.95（范围14 - 163），NMS负担等级为4级，非常严重；PD组的得分为41.97±35.45（范围：0 - 215），NMS负担等级为3级，严重。比较分析表明，PSP患者的NMS总分（<0.0001）、睡眠/疲劳（=0.0007）、情绪/淡漠（=0.0001）、胃肠道（<0.0001）和排尿功能障碍（=0.0001）域比PD患者明显更严重。这项观察性研究报告称，PSP患者的NMS非常常见，因此与PD相比，PSP患者中NMS的负担更高，具体与情绪/淡漠、注意力/记忆、胃肠道、排尿障碍有关。
