Faloia E, Filipponi S, Mancini V, Morosini P, De Pirro R
Clinica di Endocrinologia, Università di Ancona, Italy.
J Endocrinol Invest. 1993 Oct;16(9):675-7. doi: 10.1007/BF03348907.
Six women with acne and six women with hirsutism were treated with the GnRH analog [D-Ser(Bu(t))6] LHRH-(1-9)ethylamide (Buserelin) for 6 months (nasal spray, 1,200 micrograms/day) to suppress ovarian steroidogenesis. All women were eumenorrheic and did not demonstrate any adrenal or ovarian dysfunction. During treatment, ovarian steroids, LH and FSH decreased, while DHEA-S showed minor modifications; the clinical score for both acne and hirsutism showed a significant reduction. Moreover, acne and hirsutism were still well controlled 6 months after therapy. Gonadal function resumed in all patients after discontinuation of therapy. Three patients suffered from hot flashes from the 4th month. These data demonstrate that suppression of ovarian steroid secretion might be an efficient treatment in women suffering from acne or idiopathic hirsutism, indicating that ovarian steroids may have a key-role in the pathogenesis of these conditions.
六名患有痤疮的女性和六名患有多毛症的女性接受了促性腺激素释放激素类似物[D-丝氨酸（叔丁基）6]促黄体生成素释放激素-（1-9）乙酰胺（布舍瑞林）治疗6个月（鼻喷雾剂，每日1200微克），以抑制卵巢类固醇生成。所有女性月经周期正常，未表现出任何肾上腺或卵巢功能障碍。治疗期间，卵巢类固醇、促黄体生成素（LH）和促卵泡生成素（FSH）下降，而硫酸脱氢表雄酮（DHEA-S）有轻微变化；痤疮和多毛症的临床评分均显著降低。此外，治疗后6个月，痤疮和多毛症仍得到良好控制。停药后所有患者的性腺功能恢复。三名患者从第4个月开始出现潮热。这些数据表明，抑制卵巢类固醇分泌可能是治疗患有痤疮或特发性多毛症女性的有效方法，这表明卵巢类固醇可能在这些病症的发病机制中起关键作用。
