Lucky A W, McGuire J, Rosenfield R L, Lucky P A, Rich B H
J Invest Dermatol. 1983 Jul;81(1):70-4. doi: 10.1111/1523-1747.ep12539043.
We have studied a group of young adult women of mean age 23.8 +/- 6.5 (SD) years with only acne (A, n = 46), only hirsutism (H, n = 10), and acne plus hirsutism (A + H, n = 19) who sought dermatologic care. We measured the androgens, total and free testosterone (T), free 17 beta-hydroxysteroids (17-beta), dehydroepiandrosterone sulfate (DS), and the androgen precursors 17 alpha-hydroxypregnenolone (17-Preg) and 17 alpha-hydroxyprogesterone (17-Prog), as well as testosterone-estrogen binding globulin in all patients. Plasma hormone levels of the patients were compared to those of 23 controls of mean age 25.6 +/- 6.6 years who had neither acne nor hirsutism. Mean levels of all hormones measured, except 17-Preg, were elevated in the women with acne. Fifty-two percent of Group A, 60% of Group H, and 63% of Group A + H patients had at least one abnormal hormone level. The most frequently elevated plasma androgens in all the women with acne were: free T 25%, free 17-beta 23%, and DS 19%. Total T was high in only 12%. Elevations of plasma androgens were present in some women who did not have hirsutism or irregular menses. Identification of endocrine abnormalities in women with acne may potentially offer an opportunity for hormonal therapy.
我们研究了一组平均年龄为23.8±6.5（标准差）岁的年轻成年女性，她们因痤疮（A组，n = 46）、多毛症（H组，n = 10）或痤疮合并多毛症（A + H组，n = 19）前来皮肤科就诊。我们测量了所有患者的雄激素，包括总睾酮和游离睾酮（T）、游离17β-羟基类固醇（17-β）、硫酸脱氢表雄酮（DS）以及雄激素前体17α-羟孕烯醇酮（17-Preg）和17α-羟孕酮（17-Prog），还有睾酮 - 雌激素结合球蛋白。将患者的血浆激素水平与23名平均年龄为25.6±6.6岁、既无痤疮也无多毛症的对照组进行比较。除17-Preg外，所有测量激素的平均水平在痤疮女性中均升高。A组52%、H组60%和A + H组63%的患者至少有一项激素水平异常。在所有痤疮女性中，最常升高的血浆雄激素为：游离T 25%、游离17-β 23%、DS 19%。总T仅12%升高。一些没有多毛症或月经不规律的女性也存在血浆雄激素升高的情况。识别痤疮女性的内分泌异常可能为激素治疗提供机会。
