Kirkland J L, Hollenberg C H, Kindler S, Gillon W S
Institute of Medical Science, Faculty of Medicine, University of Toronto, Canada.
J Gerontol. 1994 Jan;49(1):B31-5. doi: 10.1093/geronj/49.1.b31.
Preadipocytes are cells which are capable of either replication or of differentiation into fat cells. As with other stem or progenitor cell types, the replicative capacity of preadipocytes declines with increasing age; however, little information about effects of age on preadipocyte cell number in vivo is available. We determined preadipocyte number in the perirenal and epididymal fat depots of 3-, 17-, and 27-month-old Fischer 344 rats in 23 experiments. Increasing age was not associated with a decrease in preadipocyte number; indeed, the number of preadipocytes increased in epididymal depots throughout maturation and senescence. Hence, the tenet that aging causes a decline in the size of stem cell or progenitor pools is not generalizable to all tissues, even if the cells exhibit reduced replicative capacity in culture.
前脂肪细胞是一种能够进行复制或分化为脂肪细胞的细胞。与其他干细胞或祖细胞类型一样，前脂肪细胞的复制能力会随着年龄的增长而下降；然而，关于年龄对体内前脂肪细胞数量影响的信息却很少。我们在23项实验中测定了3个月、17个月和27个月大的Fischer 344大鼠肾周和附睾脂肪库中的前脂肪细胞数量。年龄的增长与前脂肪细胞数量的减少并无关联；事实上，在整个成熟和衰老过程中，附睾脂肪库中的前脂肪细胞数量都在增加。因此，衰老会导致干细胞或祖细胞池大小下降这一原则并不适用于所有组织，即使这些细胞在培养中表现出复制能力下降。
