Szabo R M, Sharkey N A
Department of Orthopaedic Surgery, University of California, Davis, Sacramento.
J Orthop Res. 1993 Nov;11(6):828-33. doi: 10.1002/jor.1100110608.
Repetitive cyclic loading of a nerve has been proposed as a pathogenic factor in the development of occupational compression neuropathies. Little is known about the basic response of peripheral nerve to cyclic compression. We investigated the hypothesis that cyclic compression is more detrimental to nerve function than constant compression. We measured the amplitudes and velocities of distally evoked action potentials in the presence of constant or cyclic compression of the tibial nerve in rats. Seven groups were subjected to constant or cyclic compression for 6 h by a computer controlled, hydraulically activated compression chamber. Nerves were compressed with 0 (control group), 30, 60, or 90 mm Hg of constant pressure or 0-30, 20-50, or 30-60 mm Hg of cyclic compression for approximately 20,000 compression cycles. Action potentials were recorded every 15 min. The effects of cyclic compression on nerve conduction were equivalent to the effects of constant compression at the average applied pressure. Cyclic loading itself does not appear to be an important pathogenic factor in the development of nerve conduction block.
神经的重复性循环负荷已被认为是职业性压迫性神经病变发展中的一个致病因素。关于周围神经对循环压迫的基本反应知之甚少。我们研究了这样一个假设，即循环压迫比持续压迫对神经功能更具损害性。我们在大鼠胫神经受到持续或循环压迫的情况下，测量了远端诱发动作电位的幅度和速度。七组大鼠通过计算机控制的液压激活压缩室分别接受6小时的持续或循环压迫。神经分别以0（对照组）、30、60或90毫米汞柱的恒定压力或0 - 30、20 - 50或30 - 60毫米汞柱的循环压力进行压迫，约20,000次压缩循环。每15分钟记录一次动作电位。在平均施加压力下，循环压迫对神经传导的影响与持续压迫的影响相当。循环负荷本身似乎并不是神经传导阻滞发展中的一个重要致病因素。
