McMillan M D, Smith C J, Smillie A C
Department of Oral Biology, School of Dentistry, Dunedin, New Zealand.
J Oral Pathol Med. 1993 Sep;22(8):368-73. doi: 10.1111/j.1600-0714.1993.tb01091.x.
Canalicular adenomas from five patients were examined by light and electron microscopy. All patients were over 50 years of age; 4 of the lesions were from the upper lip, 4 were cystic, 2 showed capsular invasion and 1 was multifocal. Histopathologically there were epithelial duct-like or canalicular structures cut at various angles and epithelial islands surrounded by hyalinized and mucinous connective tissue that contained little collagen. Ultrastructurally the epithelial islands contained many small lumina and connective tissue islands. The characteristic epithelial cell was columnar or cuboidal, extended from the lumina to the connective tissue, had almost straight lateral cell boundaries with desmosomes that predominated near the lumina, and possessed gap junctions and a small number of tight junctions. Their main cytoplasmic constituents were ribosomes, mitochondria, rough-surfaced endoplasmic reticulum and microfilaments. These findings show that canalicular adenomas are truly monomorphic and support the concept that they are derived from the cells of excretory ducts.
对5例患者的小管腺瘤进行了光镜和电镜检查。所有患者均超过50岁；4个病变位于上唇，4个为囊性，2个显示有包膜侵犯，1个为多灶性。组织病理学上，有以不同角度切开的上皮导管样或小管结构以及被透明化和黏液性结缔组织包围的上皮岛，该结缔组织含少量胶原。超微结构上，上皮岛内有许多小腔隙和结缔组织岛。特征性上皮细胞为柱状或立方形，从腔隙延伸至结缔组织，其细胞外侧边界几乎呈直线，在靠近腔隙处有占主导的桥粒，并具有缝隙连接和少量紧密连接。其主要胞质成分是核糖体、线粒体、粗面内质网和微丝。这些发现表明小管腺瘤是真正的单形性肿瘤，并支持它们起源于排泄管细胞的观点。
