Slowik F, Lapis K, Takács J
Acta Morphol Acad Sci Hung. 1979;27(4):235-49.
Ultrastructural examination of 28 human pituitary adenomas was performed. Findings were correlated to the clinical history and light microscopic observations. As revealed by light and electron microscopy 15 adenomas were of the chromophobe type causing no endocrine dysfunction. In 8 cases acidophilic adenomas were associated with endocrine symptoms. In this group two adenomas were of the densely granulated type, whereas 6 of the sparsely granulated type. The latter showed marked ultrastructural signs of enhanced secretory activity. Five cases corresponding electronmicroscopically to sparsely granulated acidophilic adenomas but causing no endocrine symptoms constituted a separate group. They suggest the possibility of the production of abnormal proteins by this type of adenoma cells. Oncocyte cell-groups were seen in chromophobe adenomas. Morphometric data on granule size and distribution proved to be useful in the differentiation of chromophobe and acidophilic adenomas. Hypertrophic cell organelles, filamentous and tubular structures are interpreted as ultrastructural signs of cellular adaptation.
对28例人类垂体腺瘤进行了超微结构检查。检查结果与临床病史及光镜观察结果相关联。光镜和电镜检查显示，15例腺瘤为嫌色细胞型，未引起内分泌功能障碍。8例嗜酸性腺瘤伴有内分泌症状。在这一组中，2例腺瘤为密集颗粒型，而6例为稀疏颗粒型。后者显示出分泌活动增强的明显超微结构迹象。5例电镜检查对应于稀疏颗粒型嗜酸性腺瘤但未引起内分泌症状的病例构成一个单独的组。它们提示了这种类型的腺瘤细胞产生异常蛋白质的可能性。在嫌色细胞腺瘤中可见嗜酸性细胞群。颗粒大小和分布的形态学数据被证明有助于鉴别嫌色细胞腺瘤和嗜酸性腺瘤。肥大的细胞器、丝状和管状结构被解释为细胞适应的超微结构迹象。
