Stein J P, Huffman J L, Freeman J A, Boyd S D, Lieskovsky G, Skinner D G
Department of Urology, University of Southern California School of Medicine, Los Angeles.
J Urol. 1994 Feb;151(2):338-40. doi: 10.1016/s0022-5347(17)34942-x.
Between August 1982 and May 1988, 503 patients underwent construction of a continent ileal reservoir (Kock pouch) for cutaneous urinary diversion at our university. Stenosis of the afferent antireflux valve resulted in upper urinary tract obstruction in 11 patients (2%). In addition, 2 patients underwent Kock pouch diversion elsewhere and upon referral to our institution they had afferent valve stenosis. To date 13 patients have been identified with this problem. Hydronephrosis was present in 100% of the functional kidneys in these patients. Radiographs of the Kock pouch were uniformly normal without evidence of reflux or other pathological condition. The most common presenting symptom was flank pain in 7 patients (54%) and the most common presenting sign was creatinine elevation above baseline in 7 (54%). Infections recurred with or without sepsis in 5 patients (38%). Ureteroileal anastomotic strictures were not present in any patient. The interval from creation of the Kock pouch to the diagnosis of stenosis ranged from 2 to 75 months (mean 39). All patients underwent endoscopic evaluation of the Kock pouch confirming stenosis of the afferent antireflux valve, and subsequent mechanical dilation of the stenotic valve. Dilation procedures were repeated in 6 patients (46%), 4 of whom subsequently required open surgical revision of the afferent valve. Of these patients 3 are clinically stable and 1 died of the primary malignancy. The remaining 2 patients are clinically and radiographically stable after multiple dilations. Of the 7 patients (54%) requiring only a single dilation 6 are clinically stable and 1 died of the primary malignancy. Stenosis of the afferent antireflux valve of the Kock pouch, previously unreported to our knowledge, is a rare late complication leading to flank pain, hydronephrosis, recurrent infection and elevation of serum creatinine levels. Approximately 50% of the patients respond to a single dilation of the nipple valve. However, most patients who require repeat dilation will need open surgical revision.
1982年8月至1988年5月期间,我校有503例患者接受了用于皮肤造口尿液改道的可控回肠膀胱术(Kock袋)。输入抗反流瓣膜狭窄导致11例患者(2%)出现上尿路梗阻。此外,有2例患者在其他地方接受了Kock袋改道手术,转诊至我院时发现存在输入瓣膜狭窄。迄今为止,已确认13例患者存在此问题。这些患者中,功能肾均出现了肾积水。Kock袋的X线片均正常,无反流或其他病理状况的证据。最常见的症状是7例患者(54%)出现胁腹痛,最常见的体征是7例患者(54%)肌酐水平高于基线。5例患者(38%)反复发生感染,有或无脓毒症。所有患者均未出现输尿管回肠吻合口狭窄。从Kock袋构建至狭窄诊断的时间间隔为2至75个月(平均39个月)。所有患者均接受了Kock袋的内镜评估,证实输入抗反流瓣膜狭窄,随后对狭窄瓣膜进行了机械扩张。6例患者(46%)重复进行了扩张手术,其中4例随后需要对输入瓣膜进行开放手术修复。这些患者中,3例临床稳定,1例死于原发性恶性肿瘤。其余2例患者在多次扩张后临床和影像学表现稳定。在仅需单次扩张的7例患者(54%)中,6例临床稳定,1例死于原发性恶性肿瘤。据我们所知,此前未报道过Kock袋输入抗反流瓣膜狭窄,这是一种罕见的晚期并发症,可导致胁腹痛、肾积水、反复感染和血清肌酐水平升高。约50%的患者单次扩张乳头瓣膜有效。然而,大多数需要重复扩张的患者将需要进行开放手术修复。