Montorsi F, Guazzoni G, Bergamaschi F, Consonni P, Rigatti P, Pizzini G, Miani A
Institute of Human Anatomy, Scientific Institute H. San Raffaele, Milan, Italy.
J Urol. 1994 Feb;151(2):373-5. doi: 10.1016/s0022-5347(17)34952-2.
We attempted to clarify the role of color Doppler sonography in assessing the vascular function of untreated Peyronie's disease. A total of 50 patients with a mean 20-month history of penile curvature underwent color Doppler sonography with the penis in the flaccid state and after intracavernous injection of 20 micrograms. prostaglandin E1. Of the patients 41 (82%) complained of various degrees of erectile dysfunction, while 9 (18%) reported sustained rigid erections. Pathological peak systolic flow velocities (less than 30 cm. per second) of the cavernous arteries were found bilaterally in 10 patients (20%) and unilaterally in 10 (20%). Peak systolic flow velocity correlated positively with cavernous artery flow volume and with acceleration. Cavernous artery end diastolic velocity and resistance index, measured 15 and 30 minutes after vasoactive injection and genital manipulation, were indicative of corporeal veno-occlusive dysfunction (greater than 10 and less than 0.75 cm. per second, respectively) in 32 patients (65%). Of these patients, 11 (22%) had mixed arteriovenous dysfunction and 9 (18%) had normal cavernous artery flow velocities. Flow along the cavernous arteries is sometimes altered in cases of Peyronie's disease while corporeal veno-occlusive dysfunction seems to be the main hemodynamic abnormality. Color Doppler sonography should be considered as the initial step in the diagnostic evaluation of patients with Peyronie's disease who may be eligible for surgical treatment.
我们试图阐明彩色多普勒超声在评估未经治疗的佩罗尼氏病血管功能中的作用。共有50例阴茎弯曲平均病史20个月的患者接受了彩色多普勒超声检查，检查时阴茎处于疲软状态，以及在海绵体内注射20微克前列腺素E1之后。41例（82%）患者抱怨有不同程度的勃起功能障碍，而9例（18%）报告有持续的坚硬勃起。10例患者（20%）双侧海绵体动脉的病理收缩期峰值流速（小于每秒30厘米）被发现，10例（20%）为单侧。收缩期峰值流速与海绵体动脉血流量及加速度呈正相关。在血管活性药物注射和生殖器操作后15分钟及30分钟测量的海绵体动脉舒张末期流速和阻力指数，在32例患者（65%）中提示海绵体静脉闭塞功能障碍（分别大于每秒10厘米和小于0.75厘米）。在这些患者中，11例（22%）有动静脉混合功能障碍，9例（18%）海绵体动脉流速正常。佩罗尼氏病患者的海绵体动脉血流有时会改变，而海绵体静脉闭塞功能障碍似乎是主要的血流动力学异常。对于可能适合手术治疗的佩罗尼氏病患者，彩色多普勒超声应被视为诊断评估的第一步。
