Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, P.O. Box 19395-1849, Tehran, Iran.
Int Urol Nephrol. 2012 Dec;44(6):1631-40. doi: 10.1007/s11255-012-0284-z. Epub 2012 Sep 16.
To investigate the impact of immediate surgical repair and conservative treatment of penile fracture (PF) on penile vascular indices.
The study includes 146 surgically treated (group 1), and 56 conservatively treated patients (group 2). All of the participants underwent penile duplex Doppler ultrasonography (PDDU), and Doppler parameters including the peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) were measured in both corpora at baseline and after intracavernosal injection of 20 μg prostaglandin E1. Univariable and multivariable Cox regression analysis addressed study variables.
An increased number of men in group 2 (25.0%) compared with men in group 1 (19.2%) reported ED, but the difference did not reach statistical significance (P=0.06). In patients with ED the mean PSV did not differ significantly between the group 1 (30.1±4.02 cm/s) and group 2 (30.1±4.02 cm/s) (P=0.32). Also, in patients without ED, the mean PSV for group 1 (82.4±24.1 cm/s) subjects did not differ significantly from the means for the group 2 patients (79.4±27.2 cm/s) (P=0.21). Vascular hemodynamics in fractured corpus cavernosum did not differ significantly between two groups (P=0.08).
Current method of surgical treatment does not provide better outcome in terms of erectile function and penile vascular hemodynamics.
研究阴茎破裂(PF)即时手术修复与保守治疗对阴茎血管指数的影响。
本研究纳入 146 例手术治疗患者(1 组)和 56 例保守治疗患者(2 组)。所有患者均行阴茎双功能多普勒超声检查(PDDU),并在基线时和经海绵体内注射 20μg 前列腺素 E1 后测量阴茎海绵体的收缩期峰值速度(PSV)、舒张末期速度(EDV)和阻力指数(RI)等多普勒参数。采用单变量和多变量 Cox 回归分析研究变量。
与 1 组(19.2%)相比,2 组(25.0%)中报告 ED 的男性人数更多,但差异无统计学意义(P=0.06)。在 ED 患者中,1 组(30.1±4.02cm/s)和 2 组(30.1±4.02cm/s)的平均 PSV 无显著差异(P=0.32)。此外,在无 ED 的患者中,1 组(82.4±24.1cm/s)的平均 PSV 与 2 组(79.4±27.2cm/s)的平均值无显著差异(P=0.21)。两组患者的破裂海绵体的血管血流动力学无显著差异(P=0.08)。
目前的手术治疗方法在勃起功能和阴茎血管血流动力学方面并不能提供更好的结果。