Shuto R, Fujioka T, Kodama R, Nasu M
Second Department of Internal Medicine, Oita Medical University.
Nihon Rinsho. 1993 Dec;51(12):3132-7.
Japanese monkeys were studied for one month from 6 months (short-term) after inoculation of Helicobacter pylori, and two years (long-term). In the short-term study, macroscopic and histological gastritis were observed for 5 infected monkeys. The gastritis score, the ammonia concentration in the gastric secretion and the level of serum antibody (IgG) were higher for the infected group than for the control. In the long term study, H. pylori was always recovered for 2 years in the infected group, and the gastritis score was higher than the control. The intracellular periodic acid-Schiff (PAS) positive substances in the infected group decreased than that of the control. The tall of pyloric gland in the infected group was significantly decreased on 6 months from 1.5 years. These results suggest that the Japanese monkey can be used as experimental model of H. pylori infection and that H. pylori can induce chronic active gastritis similar to human.
对日本猕猴在接种幽门螺杆菌后6个月（短期）进行了为期1个月的研究，并进行了为期两年（长期）的研究。在短期研究中，观察到5只感染猕猴出现了宏观和组织学胃炎。感染组的胃炎评分、胃分泌物中的氨浓度和血清抗体（IgG）水平均高于对照组。在长期研究中，感染组在2年内始终能检测到幽门螺杆菌，且胃炎评分高于对照组。感染组细胞内过碘酸希夫（PAS）阳性物质比对照组减少。感染组幽门腺高度在1.5年后6个月时显著降低。这些结果表明，日本猕猴可作为幽门螺杆菌感染的实验模型，且幽门螺杆菌可诱发类似于人类的慢性活动性胃炎。
