Yoshida J, Asaka M
Third Department of Internal Medicine, Hokkaido University School of Medicine.
Nihon Rinsho. 1993 Dec;51(12):3196-200.
The 13C-urea breath test is now a practical and readily available alternative to endoscopy- and serology-based methods for the detection of H. pylori infection. It can detect very low levels of H. pylori colonization within the stomach by assessing the entire mucosa, and avoids the risks of sampling error. We performed the 13C-urea breath test in asymptomatic volunteers and patients with gastric and duodenal ulcers in order to compare the sensitivity and specificity by measurement of H. pylori antibody by ELISA. The positive rates of H. pylori in the 13C-urea breath test was correspondent with the results from the H. pylori antibody test, although no correlation in the antibody titers and urease activities was observed between the two methods. The 13C-urea breath test was the most useful method in evaluation of eradication of H. pylori after administration of antibiotics, compared to serological and pathological methods. These results suggest that the 13C-urea breath test is highly useful for the diagnosis of H. pylori infection of the gastric mucosa.
13C尿素呼气试验现已成为一种实用且易于获得的检测幽门螺杆菌感染的方法，可替代基于内镜检查和血清学的方法。它通过评估整个胃黏膜，能够检测出胃内极低水平的幽门螺杆菌定植，并且避免了采样误差的风险。我们对无症状志愿者以及患有胃溃疡和十二指肠溃疡的患者进行了13C尿素呼气试验，以便通过酶联免疫吸附测定法（ELISA）检测幽门螺杆菌抗体来比较其敏感性和特异性。13C尿素呼气试验中幽门螺杆菌的阳性率与幽门螺杆菌抗体检测结果一致，尽管两种方法之间未观察到抗体滴度与尿素酶活性的相关性。与血清学和病理学方法相比，13C尿素呼气试验是评估抗生素治疗后幽门螺杆菌根除情况最有用的方法。这些结果表明，13C尿素呼气试验对胃黏膜幽门螺杆菌感染的诊断非常有用。
