Kubota T, Ito A, Shiota K, Fujioka T
2nd Department of Internal Medicine, Oita Medical University.
Nihon Rinsho. 1993 Dec;51(12):3221-6.
Patients with intractable peptic ulcer or recurrent peptic ulcer have high rate of Helicobacter pylori infection. To study the effect of H. pylori on the recurrence of peptic ulcer, we treated the patients, who had H. pylori infection, with antibiotics (amoxicillin, clarithromycin, fosfomycin). After one year, none of peptic ulcer patient in whom H. pylori was eradicated had a recurrence. Among patients who remained positive for H. pylori, the ulcer relapse rate was 61% (11 of 18). In patients who were successfully eradicated of H. pylori with antibiotics the rate of recurrence was reduced. Patients with both intractable peptic ulcer and H. pylori infection were treated with antibiotics. Eradication of H. pylori induced ulcer healing. These findings suggest an important role for H. pylori in intractable and recurrent peptic ulcer.
患有顽固性消化性溃疡或复发性消化性溃疡的患者幽门螺杆菌感染率很高。为了研究幽门螺杆菌对消化性溃疡复发的影响，我们用抗生素（阿莫西林、克拉霉素、磷霉素）治疗了幽门螺杆菌感染的患者。一年后，幽门螺杆菌被根除的消化性溃疡患者无一复发。在幽门螺杆菌仍呈阳性的患者中，溃疡复发率为61%（18例中的11例）。用抗生素成功根除幽门螺杆菌的患者复发率降低。患有顽固性消化性溃疡且感染幽门螺杆菌的患者用抗生素治疗。根除幽门螺杆菌可促使溃疡愈合。这些发现表明幽门螺杆菌在顽固性和复发性消化性溃疡中起重要作用。
