[胃癌中的幽门螺杆菌感染]

[Helicobacter pylori infection in gastric cancer].

作者信息

Hayashi S, Saito D, Fukuda H, Noda T, Yoshida S, Katoh M, Oguro Y, Sugimura T, Terada M

出版信息

Nihon Rinsho. 1993 Dec;51(12):3236-41.

Abstract

The relationship between Helicobacter pylori (H. pylori) infection and gastric cancer becomes the topics in the world, since some reports thereon in 1991. The purpose of this study was to know the prevalence of H. pylori infection in many patients with gastric cancer. We examined the H. pylori IgG antibody in 507 patients with gastric cancer resected surgically in our hospital from 1989 to 1991, retrospectively. For the test of H. pylori IgG antibody, HM-CAP EIA kit (Italy, ENTERIC PRODUCTS Co.) was used. The overall detection rate of H. pylori IgG antibody was 75% (378/507). H. pylori infection was significant significantly frequent in early cancer (80%, 231/288) than advanced cancer (67%, 147/219). But, the other clinicopathological features such as sex, age, histological type, location and the degree of intestinal metaplasia were not significantly correlated with H. pylori infection. To evaluate the risk of H. pylori infection for gastric cancer, we are going to plan a matched-pair case-control study.

摘要

自1991年有关幽门螺杆菌（H. pylori）感染与胃癌关系的一些报道以来，这一关系成为全球关注的话题。本研究的目的是了解众多胃癌患者中幽门螺杆菌感染的患病率。我们回顾性检测了1989年至1991年在我院接受手术切除的507例胃癌患者的幽门螺杆菌IgG抗体。幽门螺杆菌IgG抗体检测采用HM-CAP EIA试剂盒（意大利，ENTERIC PRODUCTS公司）。幽门螺杆菌IgG抗体的总体检测率为75%（378/507）。幽门螺杆菌感染在早期癌症（80%，231/288）中显著比晚期癌症（67%，147/219）更常见。但是，其他临床病理特征，如性别、年龄、组织学类型、部位和肠化生程度与幽门螺杆菌感染无显著相关性。为评估幽门螺杆菌感染对胃癌的风险，我们计划开展一项配对病例对照研究。