Williams P, Aronson J, Sleight P
Lancet. 1978;2(8104-5):1340-2. doi: 10.1016/s0140-6736(78)91976-1.
64 of 910 hospital patients taking digoxin had a ventricular rate of less than 60 beats/min. In only 6 out of 57 of those investigated further could a diagnosis of digoxin toxicity be made on clinical, electrocardiographic, and biochemical grounds. No reason for the slow heart-rate could be found in 42 patients. Excessive vagal effects of digoxin in resting subjects may cause the bradycardia found in these in patients in the absence of digitalis toxicity.
910名服用地高辛的住院患者中有64人心室率低于60次/分钟。在进一步调查的57人中，只有6人能根据临床、心电图和生化检查结果确诊为地高辛中毒。42名患者未发现心率缓慢的原因。地高辛对静息状态下的受试者产生的过度迷走神经效应可能是这些患者出现心动过缓的原因，而并非存在洋地黄毒性。
