Ochotny R, Mitkowski P
I Kliniki Kardiologii Instytutu Kardiologii Akademii Medycznej im. Karola Marcinkowskiego, Poznaniu.
Pol Arch Med Wewn. 1993 Sep;90(3):211-7.
A quantitative and qualitative analysis of ventricular arrhythmia was performed in 120 patients (64 men and 56 women, mean age 54 +/- 16) who suffered from arterial hypertension or congestive heart failure in the course of organic heart disease or ischaemic heart disease. 60 of them were treated with diuretics and the other 60 were control group. Neither antiarrhythmic drugs nor digitalis were used. There were no signs of left ventricular hypertrophy. Most patients treated with diuretics received potassium supplementation. Besides clinical examination all patients underwent 24 hours monitoring of Holter ECG. 38 patients treated with diuretics were evaluated before and after 6 months of therapy. In the diuretic group significantly higher percentage of patients with greater density of premature ventricular beats (count of premature ventricular beats [PVB]/100,000 heart evolutions) was observed. Number of patients with complex ventricular arrhythmia (Lown IVa and IVb) was also greater in this group. Serum levels of potassium and magnesium fell within the normal range, but the latter was significantly lower (p < 0.05) in those treated with diuretics.
对120例患者（64例男性和56例女性，平均年龄54±16岁）进行了室性心律失常的定量和定性分析，这些患者患有器质性心脏病或缺血性心脏病，伴有动脉高血压或充血性心力衰竭。其中60例接受利尿剂治疗，另外60例为对照组。未使用抗心律失常药物和洋地黄。无左心室肥厚迹象。大多数接受利尿剂治疗的患者补充了钾。除临床检查外，所有患者均接受了24小时动态心电图监测。对38例接受利尿剂治疗的患者在治疗6个月前后进行了评估。在利尿剂组中，观察到室性早搏密度更高（室性早搏计数[PVB]/100,000次心搏）的患者比例显著更高。该组中复杂性室性心律失常（Lown IVa和IVb）患者的数量也更多。血清钾和镁水平在正常范围内，但接受利尿剂治疗的患者中镁水平显著较低（p<0.05）。
