Oyen R H, Van Poppel H P, Ameye F E, Van de Voorde W A, Baert A L, Baert L V
Department of Radiology, University Hospitals, Catholic University of Leuven, Belgium.
Radiology. 1994 Feb;190(2):315-22. doi: 10.1148/radiology.190.2.8284375.
To ascertain the reliability of computed tomography (CT) and CT-guided fine-needle aspiration biopsy (FNAB) in staging of lymph nodes in patients with locally confined prostatic carcinoma.
A total of 285 patients were studied prospectively. FNAB was performed in 43 patients (15%) with lymph nodes suspect for metastasis on CT scans. FNAB findings were correlated with either the findings of the pathologic examination performed after lymph node dissection (LND) or the status of the lymph node at follow-up with CT after hormone therapy.
The sensitivity, specificity, and accuracy of CT-guided FNAB were 77.8%, 100%, and 96.5%. If CT only had been performed, these results would have been 77.8%, 96.7%, and 93.7%. CT staging was false-negative in only 10 patients, who had microscopic metastatic deposits in a solitary lymph node.
Combined CT and FNAB is highly efficient for assessment of lymph node metastasis. Therefore, it could be considered an alternative to surgical or laparoscopic lymphadenectomy in patients scheduled for radical prostatectomy or curative radiation therapy.
确定计算机断层扫描（CT）及CT引导下细针穿刺活检（FNAB）在局部局限性前列腺癌患者淋巴结分期中的可靠性。
前瞻性研究共纳入285例患者。对CT扫描怀疑有转移的43例（15%）患者进行了FNAB。FNAB结果与淋巴结清扫（LND）后病理检查结果或激素治疗后CT随访的淋巴结状态相关。
CT引导下FNAB的敏感性、特异性和准确性分别为77.8%、100%和96.5%。若仅行CT检查，这些结果分别为77.8%、96.7%和93.7%。仅10例患者CT分期为假阴性，这些患者在单个淋巴结中有微小转移灶。
CT与FNAB联合应用对评估淋巴结转移高效。因此，对于计划行根治性前列腺切除术或根治性放射治疗的患者，可考虑将其作为手术或腹腔镜淋巴结清扫术的替代方法。
