Trerotola S O, Lund G B, Samphilipo M A, Magee C A, Newman J S, Olson J L, Anderson J H, Osterman F A
Department of Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Md.
Radiology. 1994 Feb;190(2):379-85. doi: 10.1148/radiology.190.2.8284384.
To assess the safety and efficacy of redilation of central venous stents in a growing animal model.
Palmaz stents were placed in the inferior vena cava (IVC) in 18 newborn lambs. After 5 months, vena cavography was performed. Those animals in which growth of the IVC adjacent to the stent and/or neointimal hyperplasia had resulted in a stenosis were considered candidates for redilation. Repeat vena cavography, intravascular ultrasound, and histologic examination were performed at 2 or 6 months.
A stenosis of > 20% was demonstrated in 13 animals. Redilation was performed, and a 50% mean increase in stent diameter was achieved. There were no immediate complications. Late complications included nonocclusive laminar clot (n = 2), and a bar of tissue dividing but not occluding the caval lumen (n = 1). Moderate neointimal hyperplasia occurred in all stents. Stent compression (unrelated to redilation) occurred in seven animals.
Palmaz stents can be redilated safely and effectively in an animal model of growing central veins.
评估在生长中的动物模型中对中心静脉支架进行再次扩张的安全性和有效性。
将Palmaz支架置入18只新生羔羊的下腔静脉（IVC）。5个月后，进行腔静脉造影。那些下腔静脉在支架附近生长和/或新生内膜增生导致狭窄的动物被视为再次扩张的候选对象。在2或6个月时重复进行腔静脉造影、血管内超声检查和组织学检查。
13只动物出现了>20%的狭窄。进行了再次扩张，支架直径平均增加了50%。没有即刻并发症。晚期并发症包括非闭塞性层状血栓（n = 2），以及一条分隔但未闭塞腔静脉腔的组织条带（n = 1）。所有支架均出现中度新生内膜增生。7只动物发生了支架压缩（与再次扩张无关）。
在生长中的中心静脉动物模型中，Palmaz支架可以安全有效地进行再次扩张。
