Elster A D, King J C, Mathews V P, Hamilton C A
Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1088.
Radiology. 1994 Feb;190(2):541-6. doi: 10.1148/radiology.190.2.8284413.
To determine the relative contrast of normal cranial tissues at magnetization transfer (MT) spin-echo magnetic resonance (MR) imaging.
MR imaging at 1.5 T was performed with conventional spin-echo techniques without and with off-resonance MT saturation pulses. The signal intensities of normal cranial tissues were measured in 10 healthy volunteers on spin-density- and T2-weighted images and in 10 patients on T1- weighted images obtained before and after administration of gadopentetate dimeglumine.
MT saturation produced a significant (P < .01) reduction in signal from all tissues except cerebrospinal fluid and fat. Several gray matter structures had higher signal intensity than white matter on T1-weighted MT images. After administration of gadopentetate dimeglumine, imaging with the MT sequence increased visualization of normally enhancing structures.
MT saturation pulses produce new patterns of tissue contrast that differ substantially from those seen on conventional spin-echo images.
确定在磁化传递（MT）自旋回波磁共振（MR）成像中正常颅脑组织的相对对比度。
采用1.5T磁共振成像，运用传统自旋回波技术，分别施加和不施加偏离共振的MT饱和脉冲。在10名健康志愿者的自旋密度加权和T2加权图像上，以及10名患者静脉注射钆喷酸葡胺前后获得的T1加权图像上，测量正常颅脑组织的信号强度。
MT饱和使除脑脊液和脂肪外的所有组织信号显著降低（P <.01）。在T1加权MT图像上，几个灰质结构的信号强度高于白质。静脉注射钆喷酸葡胺后，MT序列成像增加了正常强化结构的可视化。
MT饱和脉冲产生了与传统自旋回波图像显著不同的新组织对比度模式。
