Finelli D A, Hurst G C, Gullapali R P, Bellon E M
Department of Radiology, Metro-Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998.
Radiology. 1994 Feb;190(2):553-9. doi: 10.1148/radiology.190.2.8284415.
To prove that the contrast of enhancing brain lesions on post-gadolinium T1-weighted spin-echo (SE) images can be statistically significantly improved with magnetization-transfer (MT) indirect saturation.
The contrast-to-noise ratios (C/Ns) of 201 enhancing brain lesions in 110 patients were compared on conventional and MT T1-weighted SE images obtained at 1.5 T after injection of 0.05-0.10 mmol/kg gadopentetate dimeglumine or gadodiamide.
The MT T1-weighted SE images showed a 37% reduction in signal intensity of background white matter and thereby provided a 108% improvement in the C/N of enhancing brain lesions over the conventional T1-weighted SE images (P < .001).
The C/Ns obtained with single-dose gadolinium and the MT T1-weighted SE technique were twice those obtained with the conventional technique and are at least equivalent to reported values obtained with triple-dose gadolinium and conventional T1-weighted SE images.
证明通过磁化传递（MT）间接饱和技术可使钆增强后的T1加权自旋回波（SE）图像上脑内强化病变的对比度得到统计学上的显著改善。
对110例患者的201个脑内强化病变，在注射0.05 - 0.10 mmol/kg钆喷酸葡胺或钆双胺后，于1.5 T场强下获得的常规及MT T1加权SE图像上比较其对比噪声比（C/N）。
MT T1加权SE图像显示背景白质信号强度降低37%，从而使脑内强化病变的C/N相对于常规T1加权SE图像提高了108%（P <.001）。
单剂量钆和MT T1加权SE技术获得的C/N是常规技术的两倍，且至少等同于报道的三剂量钆和常规T1加权SE图像所获得的值。
