Caramello P, Forno B, Lucchini A, Pollono A M, Sinicco A, Gioannini P
Istitute of Infectious Diseases, University of Turin, Italy.
Scand J Infect Dis. 1993;25(5):663-6. doi: 10.3109/00365549309008558.
Toxoplasmosis of the central nervous system is a frequent opportunistic infection in AIDS patients, usually presenting as a mass brain lesion detected by computerized axial tomography scanning or magnetic resonance imaging. A case of diffuse meningoencephalitis with no radiological evidence of brain lesions is described. Diagnosis was made by culturing cerebrospinal fluid (CSF) on THP1 cells where tachyzoites of Toxoplasma gondii were demonstrated after 8 days of incubation by both direct observation and immunofluorescence. CSF examination with culture should be considered in AIDS patients with neurological signs and symptoms but without radiological evidence of cerebral lesions.
中枢神经系统弓形虫病是艾滋病患者常见的机会性感染，通常表现为通过计算机断层扫描或磁共振成像检测到的脑部肿块病变。本文描述了一例无脑部病变影像学证据的弥漫性脑膜脑炎病例。诊断通过在THP1细胞上培养脑脊液（CSF）进行，培养8天后，通过直接观察和免疫荧光法均证实有刚地弓形虫速殖子。对于有神经体征和症状但无脑部病变影像学证据的艾滋病患者，应考虑进行脑脊液培养检查。
