Franchimont P, Dourcy C, Legros J J, Reuter A, Vrindts-Gevaert Y, van Cauwenberge J R, Remacle P, Gaspard U, Colin C
Ann Endocrinol (Paris). 1976 May-Jun;37(3):127-56.
Homologous radioimmunoassay of human prolactin was performed and used to investigate the secretion of this pituitary hormone under normal and pathological conditions. The following data were developed in this paper: --During the menstrual cycle, prolactin levels are more elevated during ovulatory and luteal phases than during follicular phase; --During pregnancy, prolactin levels progressively increase to reach their maximum at the end of gestation; --During lactation, prolactin levels increase for the two days following delivery, then progressively decrease; --Bromocryptine oral administration drastically reduces prolactin levels within the 24 hours as it inhibits the prolactin release normally induced by suckling. Assays of prolactin is useful to define the role of this hormone in the genesis of the galactorrhea. Bromocryptine as L Dopa reduce the hyperprolactinemia either functional or tumoral in origin. TRH provokes prolactin release which is more pronounced in females than in males. Pituitary prolactin reserve may be appreciated in several pathological conditions. It appears to be of first interest to assess the residual function of the pituitary gland after surgical removal of adenoma. Depuis 1971, la prolactine humaine peut être dosée dans les milieux biologiques par méthode radio-immunologique (G. BRYANT et coll., 1971; M. L'HERMITTE et coll., 1972; H. FRIESEN et coll., 1972; SINHA et coll., 1973). En 1974 nous avons proposé une méthode de dosage radio-immunologique homologue (A. REUTER et coll., 1976). Grâce à celle-ci nous avons exploré la sécrétion de cette hormone hypophysaire dans certaines conditions normales et pathologiques.
进行了人催乳素的同源放射免疫测定，并用于研究在正常和病理条件下这种垂体激素的分泌情况。本文得出了以下数据：——在月经周期中，排卵期和黄体期的催乳素水平高于卵泡期；——在怀孕期间，催乳素水平逐渐升高，在妊娠末期达到最高值；——在哺乳期，产后两天内催乳素水平升高，然后逐渐下降；——口服溴隐亭在24小时内可显著降低催乳素水平，因为它抑制了通常由哺乳诱导的催乳素释放。催乳素测定有助于确定这种激素在溢乳发生中的作用。溴隐亭与左旋多巴一样，可降低功能性或肿瘤性高催乳素血症。促甲状腺激素释放激素可刺激催乳素释放，女性比男性更明显。在几种病理情况下可以评估垂体催乳素储备。评估腺瘤手术切除后垂体的残余功能似乎是首要关注的问题。自1971年以来，可通过放射免疫法在生物介质中检测人催乳素（G. 布莱恩特等人，1971年；M. 勒尔米特等人，1972年；H. 弗里森等人，1972年；辛哈等人，1973年）。1974年，我们提出了一种同源放射免疫测定方法（A. 罗伊特等人，1976年）。借助该方法，我们探索了在某些正常和病理条件下这种垂体激素的分泌情况。
