Bohnet H G, Mühlenstedt D, Hanker J P, Schneider H P
Arch Gynakol. 1977 Oct 28;223(3):173-8. doi: 10.1007/BF00667386.
Patients with primary infertility due to hyperprolactinemic corpus luteum insufficiency and oligomenorrhea were treated with Bromocriptin. Suppression of serum prolactin for up to four menstrual cycles resulted in a normalisation of the length of the cycle(32 vs 28 days) as well as of luteal progesterone secretion. In addition, ovulation occurred earlier after than before treatment (on day 14 vs day 18). When, however, prolactin concentrations reached levels of less than 120 muU/ml (3 ng/ml), which were observed during the 5th and 6th treatment course, reappearance of shortened luteal phase occurred probably due to oversuppression of prolactin. Premenstrual spottings were observed too. The data presented indicate that minimal prolactin is required for normal follicular maturation and luteal development. On the other hand, the gonadostat may be susceptable to the dopaminergic stimulus of Bromocriptin to a different extent as oversuppression of prolactin is not observed in hyperprolactinemic anovulatory syndromes. Thus, treatment with Bromocriptin requires a continuous monitoring of serum prolactin as well as individual treatment regimens.
患有因高催乳素血症导致黄体功能不全和月经过少的原发性不孕症患者接受了溴隐亭治疗。血清催乳素抑制长达四个月经周期，导致月经周期长度正常化（从32天变为28天）以及黄体期孕酮分泌正常化。此外，排卵在治疗后比治疗前更早发生（从第18天变为第14天）。然而，当催乳素浓度在第5和第6个疗程中降至低于120 mU/ml（3 ng/ml）时，可能由于催乳素过度抑制，黄体期再次缩短。也观察到了经前点滴出血。所呈现的数据表明，正常的卵泡成熟和黄体发育需要最低限度的催乳素。另一方面，由于在高催乳素血症无排卵综合征中未观察到催乳素过度抑制，性腺调节机制可能对溴隐亭的多巴胺能刺激有不同程度的敏感性。因此，溴隐亭治疗需要持续监测血清催乳素以及个体化的治疗方案。
