[人类精液的脂质组成与生育能力]

[Lipid composition and fertility of human ejaculate].

作者信息

Hula N M, Tron'ko M D, Volkov H L, Marhitych V M

出版信息

Ukr Biokhim Zh (1978). 1993 Jul-Aug;65(4):64-70.

Abstract

The morpho-functional indexes of ejaculates from 35 healthy and 145 infertile men were studied. The depression of functional sperm activity was found in the majority of infertile men. Phospholipid analysis of whole ejaculates from 12 healthy and 35 infertile subjects was performed. It was shown that inorganic phosphorus of total phospholipids decreased in ejaculates of men with secretory infertility. Lyso-phosphatidyl choline (LPC) was not detected in ejaculates of men with relative infertility. The amount of lyso-phosphatidyl ethanolamine (lyso-PE) and sphingomyelin in whole ejaculates of those patients decreased. The levels of LPC and lyso-PE decreased in ejaculates of persons with associated infertility. The level of phosphatidyl inositol, LPC and PE decreased in ejaculates of men with secretory infertility. The gas-lipid chromatography analysis of fatty acids composition of whole ejaculates of the infertile men showed significant changes in quantity of fatty acids. The quantity of docosahexaenoic acid in ejaculates of infertile men decreased and positively correlated with motility of spermatozoa.

摘要

对35名健康男性和145名不育男性的精液进行了形态功能指标研究。发现大多数不育男性的精子功能活性降低。对12名健康受试者和35名不育受试者的全精液进行了磷脂分析。结果表明，分泌性不育男性精液中总磷脂的无机磷含量降低。相对性不育男性的精液中未检测到溶血磷脂酰胆碱（LPC）。这些患者全精液中溶血磷脂酰乙醇胺（lyso-PE）和鞘磷脂的含量降低。合并性不育者精液中LPC和lyso-PE水平降低。分泌性不育男性精液中磷脂酰肌醇、LPC和PE水平降低。对不育男性全精液脂肪酸组成进行气相脂质色谱分析，结果显示脂肪酸数量有显著变化。不育男性精液中二十二碳六烯酸的数量减少，且与精子活力呈正相关。