Müller G, Köhler H, Stache B, Heilmann P, Kludas K H
Institut für Veterinärmedizin (Robert von Ostertag-Institut) des Bundesgesundheitsamtes, Bereich Jena.
Zentralbl Veterinarmed B. 1993 Aug;40(6):423-9.
The clearance of Pasteurella, Bordetella and Haemophilus from the lung of weaners was increased by aerogenous immunostimulations using a lysate mixture consisting of 12 strains of 8 bacterial species, as well as live and inactivated temperature sensitive mutants of Pasteurella multocida. The severity of experimental pneumonias caused by Pasteurella has also been decreased by this treatment. The effect of the lysate was shown to be unspecific and short, as antibody production against Pasteurella was not induced and no booster effect of subsequent aerogenous immunizations with Pasteurella antigens could be detected.
使用由8种细菌的12个菌株组成的裂解物混合物以及多杀性巴氏杆菌的活的和灭活的温度敏感突变体进行气源性免疫刺激，可提高断奶仔猪肺部巴氏杆菌、博德特氏菌和嗜血杆菌的清除率。这种处理还降低了由巴氏杆菌引起的实验性肺炎的严重程度。结果表明，裂解物的作用是非特异性的且持续时间短，因为未诱导出针对巴氏杆菌的抗体产生，并且未检测到随后用气源性巴氏杆菌抗原进行免疫接种的增强作用。
