[猪多杀性巴氏杆菌疫苗的进一步研发]
[Further development of P. multocida vaccines for swine].
作者信息
Schimmel D
机构信息
Institut für bakterielle Tierseuchenforschung Jena-Zwätzen, Akademie der Landwirtschaftswissenschaften.
出版信息
Berl Munch Tierarztl Wochenschr. 1990 Dec 1;103(12):410-1.
149 strains with antigen fractions of both A and D type could be found out of 446 P. multocida field strains of porcine origin. Most of them are producing the dermonecrotizing toxin. These A/D strains proved to be virulent in mice and piglets as well. In mice, the vaccination with one of the most virulent and immunogenic A/D strains, inactivated and A1(OH)3 adsorbed caused an immunity against challenge infections with P. multocida of types A, D and A/D. This effect could be confirmed on SPF piglets.
在446株猪源多杀性巴氏杆菌田间菌株中，可检出149株同时具有A和D型抗原成分的菌株。其中大多数菌株能产生皮肤坏死毒素。这些A/D型菌株在小鼠和仔猪中也表现出致病性。在小鼠中，用最具致病性和免疫原性的A/D型菌株之一进行灭活并吸附A1(OH)3后进行疫苗接种，可使其对A、D和A/D型多杀性巴氏杆菌的攻击感染产生免疫力。这种效果在无特定病原体（SPF）仔猪中也得到了证实。
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