[甲酸3,6-二甲基氨基二苯并吡啶鎓对豚鼠离体心室肌细胞动作电位和慢内向钙电流的影响]
[Effects of 3,6-dimethylamino-dibenzopyriodonium formiate on action potential and slow inward calcium current in isolated guinea pig ventricular myocytes].
作者信息
Cui Y, Tan Y H
机构信息
Department of Pharmacology, Fourth Military Medical University, Xi' an.
出版信息
Yao Xue Xue Bao. 1993;28(7):504-6.
The effects of 3,6-dimethylamino-dibenzopyriodonium formiate (IHC-64) on action potential and slow inward calcium current (I(si)) were investigated in isolated guinea pig ventricular myocytes using whole cell voltage clamp recording. IHC-64 (20 and 200 mumol/L) was shown to markedly decrease APD20 and APD90. However, in the presence of nisoldipine, no obvious effects of IHC-64 on APD20 could be detected. Under voltage clamp conditions, IHC-64 (20 and 200 mumol/L) caused a significant decrease in I(si). The results indicate that IHC-64 can block the calcium channels in isolated guinea pig ventricular myocytes.
采用全细胞电压钳记录技术，在分离的豚鼠心室肌细胞中研究了甲酸3,6-二甲基氨基二苯并吡啶鎓（IHC-64）对动作电位和慢内向钙电流（I(si)）的影响。结果显示，IHC-64（20和200 μmol/L）可显著降低APD20和APD90。然而，在尼索地平存在的情况下，未检测到IHC-64对APD20有明显影响。在电压钳条件下，IHC-64（20和200 μmol/L）可使I(si)显著降低。结果表明，IHC-64可阻断分离的豚鼠心室肌细胞中的钙通道。
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