Cheng Y H, Li L, Fu F H, Liu Y Y, Liao G T, Hou S X, Wen Y M
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Yao Xue Xue Bao. 1993;28(8):604-8.
In this paper the technique of emulsion chemical-crosslinking was used to prepare cisplatin albumin microsphere for jaw squamous cancer by neck external artery embolization. It was yellow powder with yield 80 +/- 5%, mean size 56.3 microns, cisplatin concentration 14.02-14.20%, loading rate 97.08-97.95%. The release characteristics in vitro, sterilization, stability and recipe of disperse solvent of cisplatin albumin microsphere were investigated. Animal test showed that cisplatin albumin microsphere may plug the branches of neck external artery well and remain in local tissue.
本文采用乳化化学交联技术制备顺铂白蛋白微球，用于颌面部鳞状细胞癌的颈外动脉栓塞。其为黄色粉末，收率80±5%，平均粒径56.3微米，顺铂浓度14.02 - 14.20%，载药率97.08 - 97.95%。考察了顺铂白蛋白微球的体外释放特性、灭菌、稳定性及分散溶剂配方。动物试验表明，顺铂白蛋白微球可很好地栓塞颈外动脉分支并滞留于局部组织。
