[铀动员剂的研究VI：2,3-二羟基-4-甲氧羰基苄基氨基羧酸酰胺类螯合剂的合成]
[Studies on uranium mobilization agents VI: synthesis of 2,3-dihydroxy-4-carbomethoxybenzyl aminocarboxylic acid amides chelating agents].
作者信息
Qin Z H, Xie Y Y
机构信息
Shanghai Institute of Materia Medica, Academia Sinica.
出版信息
Yao Xue Xue Bao. 1993;28(8):619-22.
PMID:8285072
Abstract
In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N-(substituted carbamoylmethyl)-2,3-dihydroxy-4-carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxication of UO2(NO3)2, CuSO4 and NiCl2 in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu2+ and Ni2+.
摘要
在寻找针对铀中毒的新型螯合疗法药物时，从邻香草醛开始合成了一系列N-羧甲基-N-（取代氨基甲酰甲基）-2,3-二羟基-4-甲氧基羰基苄胺。测试了它们对小鼠体内UO2(NO3)2、CuSO4和NiCl2解毒的效果。其中一些化合物（IVa、IVd、IVf和IVg）被证明是急性铀中毒的良好解毒剂，但对Cu2+和Ni2+的解毒效果都较差。
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