Basinger M A, Jones M M
Res Commun Chem Pathol Pharmacol. 1981 Nov;34(2):351-8.
Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) administered intraperitoneally was found to antagonize the lethal action of intraperitoneally induced uranium(VI) toxicity. In a comparative study Tiron was evaluated against Na3CaDTPA (sodium calcium diethylenetriaminepentaacetate). The ability of these compounds to detoxify the uranyl ion in simple and complexed form and their efficacy in delayed treatment regimens and determined. Toxicities of the complexes were assessed by the administration of uranyl acetate at levels of 40 mg/kg or 80 mg/kg complexed at a mole ratio of 3:1 or 2:1 of chelating agent to uranium, prior to injection, followed by two additional doses of chelating agent given one and three hours later at a 10:1 mole ratio of chelating agent to uranium. Therapy in delayed treatment regimens consisted of three injections of antidote given 20 minutes, one hour, and three hours, at a 10:1 mole ratio of chelating agent to uranium, subsequent to an injection of 40 mg/kg uranyl acetate. Survival rates for animals receiving multiple injections of Tiron were enhanced over those receiving Na3CaDTPA. The low inherent toxicity of Tiron may make it appropriate for possible clinical application.
腹腔注射的钛铁试剂(4,5-二羟基苯-1,3-二磺酸钠)被发现可拮抗腹腔注射诱导的铀(VI)毒性的致死作用。在一项对比研究中,对钛铁试剂与Na3CaDTPA(二乙烯三胺五乙酸钙钠)进行了评估。测定了这些化合物对简单形式和络合形式铀酰离子的解毒能力及其在延迟治疗方案中的疗效。通过在注射前以螯合剂与铀3:1或2:1的摩尔比络合40mg/kg或80mg/kg的醋酸铀酰来评估络合物的毒性,随后在1小时和3小时后分别以螯合剂与铀10:1的摩尔比再给予两剂螯合剂。延迟治疗方案中的治疗包括在注射40mg/kg醋酸铀酰后,以螯合剂与铀10:1的摩尔比在20分钟、1小时和3小时分别注射三次解毒剂。接受多次注射钛铁试剂的动物的存活率高于接受Na3CaDTPA的动物。钛铁试剂固有的低毒性可能使其适合于可能的临床应用。