Takata Y, Yoshizumi T, Ito Y, Hirota Y, Fujishima M
First Division of Internal Medicine, National Fukuoka Central Hospital, Japan.
Angiology. 1994 Jan;45(1):17-23. doi: 10.1177/000331979404500103.
The effect of doxazosin withdrawal on normotensive subjects was examined by ambulatory blood pressure monitoring (ABPM) during twenty-four hours. Eight normotensive volunteers were treated with doxazosin for four weeks. ABPM was done the day before withdrawal and on the second and seventh days after withdrawal. The average systolic and diastolic BP were not altered by doxazosin withdrawal either on day 2 or day 7, but pulse rate (PR) decreased on day 2 and day 7. Daytime PR decreased on day 2, but both daytime and nighttime PR decreased on day 7. On withdrawal of doxazosin, the plasma norepinephrine concentration decreased and the plasma renin activity tended to decrease. Neither overshooting hypertension nor cardiovascular event was related to doxazosin withdrawal was observed. It is concluded that, in normotensive subjects, discontinuation of doxazosin may result in bradycardia without hypotension or signs of withdrawal syndrome.
通过动态血压监测（ABPM）对血压正常的受试者在24小时内停用多沙唑嗪的影响进行了研究。八名血压正常的志愿者接受了四周的多沙唑嗪治疗。在停药前一天以及停药后的第二天和第七天进行了动态血压监测。停药后第2天和第7天，多沙唑嗪的停用均未改变平均收缩压和舒张压，但脉搏率（PR）在第2天和第7天有所下降。第2天白天的脉搏率下降，但第7天白天和夜间的脉搏率均下降。停用多沙唑嗪后，血浆去甲肾上腺素浓度降低，血浆肾素活性有降低趋势。未观察到与多沙唑嗪停药相关的血压过度升高或心血管事件。结论是，在血压正常的受试者中，停用多沙唑嗪可能导致心动过缓，而无低血压或撤药综合征迹象。
