Takata Y, Yoshizumi T, Ito Y, Hirota Y, Fujishima M
First Division of Internal Medicine, National Fukuoka Central Hospital, Japan.
Jpn Circ J. 1994 Jun;58(6):403-8. doi: 10.1253/jcj.58.403.
The effect of long-term doxazosin treatment on normotensive subjects was evaluated by 48-hour ambulatory blood pressure (BP) monitoring (ABPM). Eight normotensive volunteers were given 1 mg of doxazosin per day, and the dose was titrated every week up to 8 mg/day. The 48-hour ABPM, using a noninvasive device, was performed before treatment and during the 4th week of treatment. Doxazosin did not decrease the average 48-hour systolic BP, but diastolic BP decreased slightly (3 mmHg). This slight decrease in 48-hour diastolic BP was observed during the daytime. The 48-hour pulse rate (PR) was clearly elevated by doxazosin, which was attributed to tachycardia at night. Thus, the present study using 48-hour ABPM indicated that long-term doxazosin treatment may result in only slight daytime hypotension with apparent nighttime tachycardia in normotensive subjects.
通过48小时动态血压监测（ABPM）评估了长期服用多沙唑嗪对血压正常受试者的影响。八名血压正常的志愿者每天服用1毫克多沙唑嗪，剂量每周递增直至8毫克/天。在治疗前和治疗第4周期间，使用无创设备进行48小时ABPM。多沙唑嗪并未降低48小时平均收缩压，但舒张压略有下降（3毫米汞柱）。这种48小时舒张压的轻微下降在白天出现。多沙唑嗪使48小时脉搏率（PR）明显升高，这归因于夜间心动过速。因此，本研究采用48小时ABPM表明，长期服用多沙唑嗪可能只会导致血压正常受试者出现轻微的白天低血压，并伴有明显的夜间心动过速。
