Pastolero G C, Asa S L
Department of Pathology, St Michael's Hospital, University of Toronto, Ontario, Canada.
Arch Pathol Lab Med. 1994 Jan;118(1):79-83.
Black pigmentation of the thyroid attributed to minocycline hydrochloride is known, but to our knowledge, pigmentation associated with antidepressants has not been reported. We studied four patients with papillary carcinoma associated with thyroid pigmentation; two had received minocycline therapy, and two had received long-term treatment with antidepressants. The thyroids of patients who had been treated with minocycline were black, with pigment primarily in nontumorous tissue. The thyroids associated with antidepressant therapy were dark red, with pigment in both tumorous and nontumorous tissue. All four cases were positive for periodic acid-Schiff, periodic acid-Schiff with diastase predigestion, and Schmorl's stains and negative for Prussian blue; the results differed from those found with Fontana's technique. Minocycline-related pigmentation appears to imply a role for the iodide peroxidase system in the accumulation of pigment, whereas pigmentation attributed to intake of antidepressants appears to result from lysosomal accumulation of the drug itself.
甲状腺因盐酸米诺环素导致的黑色色素沉着是已知的，但据我们所知，与抗抑郁药相关的色素沉着尚未见报道。我们研究了4例伴有甲状腺色素沉着的乳头状癌患者；其中2例接受过米诺环素治疗，2例接受过抗抑郁药长期治疗。接受米诺环素治疗患者的甲状腺呈黑色，色素主要存在于非肿瘤组织中。与抗抑郁药治疗相关的甲状腺呈暗红色，肿瘤组织和非肿瘤组织中均有色素。所有4例病例的过碘酸希夫染色、淀粉酶预处理过碘酸希夫染色及施莫尔染色均为阳性，普鲁士蓝染色为阴性；结果与用丰塔纳技术检测的结果不同。米诺环素相关色素沉着似乎意味着碘过氧化物酶系统在色素积累中起作用，而抗抑郁药摄入导致的色素沉着似乎是药物本身在溶酶体中积累所致。
