Hyrkäs T, Ylipaavalniemi P, Oikarinen V J, Paakkari I
Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland.
Br J Oral Maxillofac Surg. 1993 Dec;31(6):351-4. doi: 10.1016/0266-4356(93)90189-4.
Fifty patients undergoing a standard removal of an impacted lower third molar were given a single dose of 75 mg sodium diclofenac or saline (placebo) intravenously before operation, on a double-blind basis. Pain was measured postoperatively by means of a visual analogue scale hourly for the first 8 h and during the first and second days after operation. Administration of diclofenac resulted in greater pain relief than administration of placebo for the first 3 h after surgery, whereafter the treatments did not differ. The results suggest that intravenous preoperative diclofenac may be useful in some clinical situations but generally it probably offers little benefit over the corresponding oral treatment.
五十名接受标准下颌阻生第三磨牙拔除术的患者，在双盲基础上，于手术前静脉注射一剂75毫克双氯芬酸钠或生理盐水（安慰剂）。术后通过视觉模拟评分法，在术后头8小时每小时测量一次疼痛程度，并在术后第一天和第二天测量。术后头3小时，使用双氯芬酸钠比使用安慰剂能更有效地缓解疼痛，此后两种治疗方法效果无差异。结果表明，术前静脉注射双氯芬酸钠在某些临床情况下可能有用，但总体而言，与相应的口服治疗相比，可能益处不大。
