Wuolijoki E, Oikarinen V J, Ylipaavalniemi P, Hampf G, Tolvanen M
Eur J Clin Pharmacol. 1987;32(3):249-52. doi: 10.1007/BF00607571.
We have treated ninety-five patients undergoing surgical removal of third molar with diclofenac or placebo, administered double-blind either pre- or postoperatively. Postoperative pain was recorded hourly for the first 8 h using a 100 mm visual analogue scale. Preoperative administration of diclofenac produced more effective pain relief than either postoperative administration or placebo. Since diclofenac has an inhibitory action on prostaglandin synthesis prophylactic intramuscular administration may have reduced the inflammatory process before synthesis of prostaglandins was activated.
我们用双氯芬酸或安慰剂对95例接受第三磨牙手术切除的患者进行了治疗，术前或术后采用双盲给药。术后8小时内，每小时使用100毫米视觉模拟评分法记录疼痛情况。术前给予双氯芬酸比术后给药或给予安慰剂能更有效地缓解疼痛。由于双氯芬酸对前列腺素合成有抑制作用，预防性肌肉注射可能在前列腺素合成被激活之前就减轻了炎症反应。
