Altaca G, Sayek I, Onat D, Gür D, Akalin E
Department of General Surgery, Bayindir Medical Center, Hacettepe University, Ankara, Turkey.
Eur J Surg. 1993 Oct;159(10):551-4.
To find out the effect of 20%, third degree burns and H2 receptor antagonists on peritoneal bactericidal activity.
Animal experiment.
Research laboratory of university school of medicine.
52 mice in five groups.
Sham burn (n = 5, group I), burned, and received subcutaneous injections of saline (0.3 ml/kg day, n = 14, group II); ranitidine (10 ml/kg/day, n = 15, group III); cimetidine (10 mg/kg/day, n = 8, group IV); or famotidine (0.7 mg/kg/day, n = 10, group V); for 14 days.
Peritoneal bactericidal activity in all groups measured 15 days after the burn.
There was a significant difference in peritoneal bactericidal activity between the control and burned mice, but no significant difference between the control group and the burned mice that were given cimetidine and famotidine.
Peritoneal bactericidal activity is suppressed in mice after 20% third degree burns and this effect may be partly reversed by cimetidine and famotidine.
探究20%三度烧伤及H2受体拮抗剂对腹膜杀菌活性的影响。
动物实验。
大学医学院研究实验室。
52只小鼠，分为五组。
假烧伤组（n = 5，第一组）；烧伤组，皮下注射生理盐水（0.3毫升/千克/天，n = 14，第二组）；雷尼替丁组（10毫升/千克/天，n = 15，第三组）；西咪替丁组（10毫克/千克/天，n = 8，第四组）；法莫替丁组（0.7毫克/千克/天，n = 10，第五组）；持续14天。
烧伤15天后测量所有组的腹膜杀菌活性。
对照组与烧伤小鼠的腹膜杀菌活性存在显著差异，但对照组与给予西咪替丁和法莫替丁的烧伤小鼠之间无显著差异。
20%三度烧伤后小鼠的腹膜杀菌活性受到抑制，西咪替丁和法莫替丁可能部分逆转这种效应。
