Ohsawa T, Hirata W, Higichi S
Chidoribashi Hospital Pharmacy, Department of Pharmacokinetics, Faculty of Pharmaceutical Science, Kyushu University, Fukuoka, Japan.
Int J Clin Pharmacol Res. 2002;22(2):29-35.
We investigated the pattern of changes in serum gastrin level produced by three H2-receptor antagonists (H2RA) in patients with gastric and duodenal ulcers between 1990 and 1999. The subjects were 51 patients (cimetidine: 18 patients; famotidine: 16 patients; ranitidine: 17 patients). The gastrin test (in the fasting and meal-stimulated states) was conducted during drug administration and on the fourth day after drug cessation. After cessation of the drug therapy, the fasting serum gastrin level was significantly lower than that during the drug therapy with the three H2RAs. Gastrin level in the fasting test was significantly higher during famotidine therapy than during cimetidine therapy (p = 0.0123). In the meal-stimulated gastrin test, the AUC of gastrin during treatment with H2RA treatment was significantly higher with famotidine than with cimetidine (p = 0.0024). The results indicate different patterns of change in the serum gastrin level in the fasting and meal-stimulated test according to the H2RA administered. Gastrin level was highest in patients administered famotidine and lowest among those administered cimetidine. The pattern of gastrin change in patients administered ranitidine was intermediate between famotidine and cimetidine.
我们研究了1990年至1999年间，三种H2受体拮抗剂（H2RA）对胃和十二指肠溃疡患者血清胃泌素水平的影响模式。研究对象为51例患者（西咪替丁组：18例；法莫替丁组：16例；雷尼替丁组：17例）。在给药期间及停药后第4天进行胃泌素检测（空腹及进食刺激状态下）。停药后，空腹血清胃泌素水平显著低于三种H2RA药物治疗期间。法莫替丁治疗期间空腹检测的胃泌素水平显著高于西咪替丁治疗期间（p = 0.0123）。在进食刺激胃泌素检测中，法莫替丁治疗期间胃泌素的曲线下面积（AUC）显著高于西咪替丁（p = 0.0024）。结果表明，根据所使用的H2RA不同，空腹及进食刺激检测中血清胃泌素水平的变化模式有所不同。法莫替丁治疗患者的胃泌素水平最高，西咪替丁治疗患者的胃泌素水平最低。雷尼替丁治疗患者的胃泌素变化模式介于法莫替丁和西咪替丁之间。
