Passive protection of mice against Actinobacillus pleuropneumoniae infection by monoclonal antibodies.

Mouse monoclonal antibodies (MAbs), Y-4b, F-6b and K-6a recognized as capsular antigens of A. pleuropneumoniae serotypes 1, 2 and 5, respectively, and MAb H-1b as lipopolysaccharide (LPS) of serotype 2 were produced. We examined the passive immunizing efficacy of these MAbs on A. pleuropneumoniae infection in C3H/HeJ mice. On the challenge infection of homologous serotype strains, they showed a sufficient protective effect in immunized mice. It was concluded that MAbs recognized as capsular antigen and LPS have a serotype-specific protective effect on A. pleuropneumoniae infection, suggesting the important role in preventing A. pleuropneumoniae infection.