Araki S, Kimura M, Suzuki M, Fujimoto M
Research and Development Division, Eisai Co., Ltd., Ibaraki, Japan.
J Vet Med Sci. 1993 Oct;55(5):899-900. doi: 10.1292/jvms.55.899.
The effect of oral administration of an active egg white product (AEWP) on neutrophil function in weanling piglets was investigated. The peripheral blood neutrophils of piglets receiving single doses of 20 mg/kg and 100 mg/kg displayed increased phagocytic activity for latex particles from 1 day after administration. This increased phagocytic activity persisted for 5 days in the 100 mg/kg group. Piglets receiving a dose of 30 mg/kg/day for a week displayed increased neutrophil phagocytic activity throughout the administration period. Moreover, when the administration of AEWP was resumed 10 days after withdrawal, neutrophil phagocytic activity rapidly increased again. Thus, AEWP enhanced the nonspecific phagocytic activity of neutrophils when given to piglets by the oral route.
研究了口服活性蛋清产品（AEWP）对断奶仔猪中性粒细胞功能的影响。接受单剂量20mg/kg和100mg/kg的仔猪外周血中性粒细胞，在给药后1天对乳胶颗粒的吞噬活性增加。这种增加的吞噬活性在100mg/kg组中持续了5天。接受30mg/kg/天剂量一周的仔猪在整个给药期间中性粒细胞吞噬活性增加。此外，停药10天后恢复给予AEWP时，中性粒细胞吞噬活性再次迅速增加。因此，口服给予仔猪AEWP可增强中性粒细胞的非特异性吞噬活性。
