Long Yanrong, Lin Sen, Zhu Jiatao, Pang Xiaoxue, Fang Zhengfeng, Lin Yan, Che Lianqiang, Xu Shengyu, Li Jian, Huang Yiming, Su Xiang, Wu De
Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture of China, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an, China.
Shanghai E.K.M biotechnolgy CO. LTD., Shang Hai, China.
Anim Sci J. 2016 Mar;87(3):411-8. doi: 10.1111/asj.12444. Epub 2015 Sep 30.
The aim of the present study was to determine the effect of dietary lysozyme levels on growth performance, gut health and non-specific immunity of weanling piglets. A total of 150 weanling piglets were allocated to six treatments. The piglets were fed the same basel diet supplemented with 0, 30, 60, 90 and 120 mg/kg lysozyme as well as antibiotics for 28 days. From day 14 to day 28 of dietary treatment, piglets fed 90 mg/kg lysozyme had greater average daily gain than piglets fed control diet. During the whole experimental period, piglets fed 120 mg/kg lysozyme tended to have greater average daily gain than piglets fed control diet. Compared with piglets fed control diet, piglets fed diets containing antibiotics and 90 mg/kg lysozyme had greater villus height to crypt depth ratio in duodenum and jejunum. Additionally, dietary supplementation of 60 and 90 mg/kg lysozyme as well as antibiotics enhanced the phagocytic activity of peritoneal macrophages in piglets. In conclusion, dietary lysozyme can accelerate the growth of weanling piglets by improving gut health and non-specific immunity and supplementing 90 mg/kg lysozyme is as effective as antibiotics (20 mg/kg colistin sulphate + 50 mg/kg kitasamycin) in improving the growth performance of weanling piglets.
本研究的目的是确定日粮中溶菌酶水平对断奶仔猪生长性能、肠道健康和非特异性免疫力的影响。总共150头断奶仔猪被分配到六种处理组。给仔猪饲喂相同的基础日粮，并分别添加0、30、60、90和120毫克/千克的溶菌酶以及抗生素，持续28天。在日粮处理的第14天至第28天，饲喂90毫克/千克溶菌酶的仔猪比饲喂对照日粮的仔猪平均日增重更高。在整个实验期间，饲喂120毫克/千克溶菌酶的仔猪平均日增重有高于饲喂对照日粮仔猪的趋势。与饲喂对照日粮的仔猪相比，饲喂含抗生素日粮和90毫克/千克溶菌酶日粮的仔猪十二指肠和空肠的绒毛高度与隐窝深度比值更高。此外，日粮中添加60和90毫克/千克溶菌酶以及抗生素可增强仔猪腹腔巨噬细胞的吞噬活性。总之，日粮溶菌酶可通过改善肠道健康和非特异性免疫力来促进断奶仔猪生长，并且添加90毫克/千克溶菌酶在改善断奶仔猪生长性能方面与抗生素（20毫克/千克硫酸黏菌素+50毫克/千克吉他霉素）效果相当。
