Jorge R E, Robinson R G, Starkstein S E, Arndt S V
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):369-74. doi: 10.1176/jnp.5.4.369.
The frequency, course, and clinical correlates of generalized anxiety disorder (GAD) and its relationship to major depression were examined in 66 patients with traumatic brain injury (TBI). Of 66 TBI patients, 7 (11%) had both GAD and major depression; 10 (15%) had major depression without GAD. Median duration was 1.5 months for nonanxious depressions, 7.5 months for anxious depressions, and 1.5 months for concurrent GAD. Anxious depressions were also associated with right hemisphere lesions, whereas major depressions alone were associated with left anterior lesions. These findings suggest that anxious major depression and major depression following TBI may be two different disorders with different underlying etiological mechanisms and perhaps differential response to treatment.
在66例创伤性脑损伤（TBI）患者中，研究了广泛性焦虑障碍（GAD）的频率、病程、临床相关因素及其与重度抑郁症的关系。66例TBI患者中，7例（11%）同时患有GAD和重度抑郁症；10例（15%）患有重度抑郁症但无GAD。非焦虑性抑郁症的中位病程为1.5个月，焦虑性抑郁症为7.5个月，同时患有GAD为1.5个月。焦虑性抑郁症也与右半球病变有关，而单独的重度抑郁症与左前病变有关。这些发现表明，TBI后的焦虑性重度抑郁症和重度抑郁症可能是两种不同的疾病，具有不同的潜在病因机制，对治疗的反应可能也不同。
